KMS Qingdao Institute of Biomass Energy and Bioprocess Technology ,CAS
| Biosynthesis of nervonic acid and perspectives for its production by microalgae and other microorganisms | |
| Fan, Yong; Meng, Hui-Min; Hu, Guang-Rong; Li, Fu- | |
| 2018-04-01 | |
| Source Publication | APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
 |
| ISSN | 0175-7598 |
| Volume | 102Issue:7Pages:3027-3035 |
| Abstract | Nervonic acid (NA) is a major very long-chain monounsaturated fatty acid found in the white matter of mammalian brains, which plays a critical role in the treatment of psychotic disorders and neurological development. In the nature, NA has been synthesized by a handful plants, fungi, and microalgae. Although the metabolism of fatty acid has been studied for decades, the biosynthesis of NA has yet to be illustrated. Generally, the biosynthesis of NA is considered starting from oleic acid through fatty acid elongation, in which malonyl-CoA and long-chain acyl-CoA are firstly condensed by a rate-limiting enzyme 3-ketoacyl-CoA synthase (KCS). Heterologous expression of kcs gene from high NA producing species in plants and yeast has led to synthesis of NA. Nevertheless, it has also been reported that desaturases in a few plants can catalyze very long-chain saturated fatty acid into NA. This review highlights recent advances in the biosynthesis, the sources, and the biotechnological aspects of NA. |
| Subtype | Review |
| Keyword | Very Long-chain Monounsaturated Fatty Acids Synthetic Biology Metabolic Engineering Cellular Engineering 3-ketoacyl-coa Synthesis |
| WOS Headings | Science & Technology ; Life Sciences & Biomedicine |
| DOI | 10.1007/s00253-018-8859-y |
| WOS Keyword | DNA-POLYMERASE-BETA ; RATE-LIMITING STEP ; CHAIN FATTY-ACIDS ; SACCHAROMYCES-CEREVISIAE ; ARABIDOPSIS-THALIANA ; YARROWIA-LIPOLYTICA ; GENE FAMILY ; 3-KETOACYL-COA SYNTHASES ; SUBSTRATE-SPECIFICITY ; MORTIERELLA-ALPINA |
| Indexed By | SCI |
| Language | 英语 |
| WOS Research Area | Biotechnology & Applied Microbiology |
| Funding Organization | National Natural Science Foundation of China(31602154) ; Shandong Province Natural Science Major Program(ZR2017ZB0209) ; Shandong Province Natural Science Funds for Young Scholar(JQ201507 ; ZR2017BC108) |
| WOS Subject | Biotechnology & Applied Microbiology |
| WOS ID | WOS:000427579600008 |
| Publisher | SPRINGER |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.qibebt.ac.cn/handle/337004/10674 |
| Collection | 中国科学院青岛生物能源与过程研究所 |
| Corresponding Author | Li, Fu- |
| Affiliation | Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao Engn Lab Single Cell Oil, Shandong Prov Key Lab Synthet Biol,Key Lab Biofue, 189 Songling Rd, Qingdao 266101, Peoples R China |
| Recommended Citation GB/T 7714 | Fan, Yong,Meng, Hui-Min,Hu, Guang-Rong,et al. Biosynthesis of nervonic acid and perspectives for its production by microalgae and other microorganisms[J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2018,102(7):3027-3035. |
| APA | Fan, Yong,Meng, Hui-Min,Hu, Guang-Rong,&Li, Fu-.(2018).Biosynthesis of nervonic acid and perspectives for its production by microalgae and other microorganisms.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,102(7),3027-3035. |
| MLA | Fan, Yong,et al."Biosynthesis of nervonic acid and perspectives for its production by microalgae and other microorganisms".APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 102.7(2018):3027-3035. |
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