A review on chiral separation by counter-current chromatography: Development, applications and future outlook

doi:10.1016/j.chroma.2017.10.073

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	A review on chiral separation by counter-current chromatography: Development, applications and future outlook
	Huang, Xin-Yi 1,2; Pei, Dong 1,2,3; Liu, Jian-Fei 1,2; Di, Duo-Long 1,2,3
	2018-01-05
发表期刊	JOURNAL OF CHROMATOGRAPHY A
ISSN	0021-9673
卷号	1531 页码:1-12
摘要	Chiral separation has been a remarkably active area of research over the past long time and it still stays that way. Over the last few decades, counter-current chromatography (CCC) was successfully applied to the field of chiral separation. It provides an attractive approach to obtain pure enantiomer, particularly in preparative application because of its unique advantages of high load capacity, low solvent consumption and easy scale-up. The last several years great strides have been made in chiral separation by CCC, ranging from novel elution modes such as recycling elution mode and multiple dual mode elution to more specialized approaches such as pH-zone-refining and biphasic chiral recognition technologies. These developments have greatly improved the resolution of enantiomers and promoted the application of CCC in the field of chiral separation. Although not as popular as its application to the field of separation of natural product, the development of chiral separation by CCC should not be underrated. In this review article, we refer to the development, applications and future outlook of chiral separation by CCC, with emphasis on topics of its history, mechanism, advantages, limitations, current development and challenges. Meanwhile, its orientation of continued evolution and future outlook also have been discussed. While some scientific and technological problems have not yet been solved thoroughly, chiral separation by CCC has demonstrated potential advantages and prospects in this field and has good chance at preparative enantioseparation. (C) 2017 Published by Elsevier B.V.
文章类型	Review
关键词	Chiral Separation High-speed Counter Current Chromatography Centrifugal Partition Chromatography
WOS标题词	Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
DOI	10.1016/j.chroma.2017.10.073
关键词[WOS]	CENTRIFUGAL PARTITION CHROMATOGRAPHY ; PERFORMANCE LIQUID-CHROMATOGRAPHY ; HYDROXYPROPYL-BETA-CYCLODEXTRIN ; IONIC LIQUIDS ; PREPARATIVE ENANTIOSEPARATION ; CAPILLARY-ELECTROPHORESIS ; ENANTIOMERIC SEPARATION ; EXPERIMENTAL-VERIFICATION ; ANALYTICAL-CHEMISTRY ; L-(+)-TARTARIC ACID
收录类别	SCI
语种	英语
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
项目资助者	National Natural Sciences Foundation of China (NSFC)(21505144 ; Natural Science Foundation of Gansu Province(1506RJZA283) ; Youth Innovation Promotion Association CAS(2016369) ; 21605149)
WOS类目	Biochemical Research Methods ; Chemistry, Analytical
WOS记录号	WOS:000423651300001
出版者	ELSEVIER SCIENCE BV
引用统计
文献类型	期刊论文
条目标识符	http://ir.qibebt.ac.cn/handle/337004/10588
专题	中国科学院青岛生物能源与过程研究所
通讯作者	Huang, Xin-Yi; Di, Duo-Long
作者单位	1.Chinese Acad Sci, Lanzhou Inst Chem Phys, CAS Key Lab Chem Northwestern Plant Resources, Lanzhou, Gansu, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou, Gansu, Peoples R China 3.Chinese Acad Sci, Lanzhou Inst Chem Phys, Ctr Resource Chem & New Mat, Qingdao, Peoples R China
推荐引用方式 GB/T 7714	Huang, Xin-Yi,Pei, Dong,Liu, Jian-Fei,et al. A review on chiral separation by counter-current chromatography: Development, applications and future outlook[J]. JOURNAL OF CHROMATOGRAPHY A,2018,1531:1-12.
APA	Huang, Xin-Yi,Pei, Dong,Liu, Jian-Fei,&Di, Duo-Long.(2018).A review on chiral separation by counter-current chromatography: Development, applications and future outlook.JOURNAL OF CHROMATOGRAPHY A,1531,1-12.
MLA	Huang, Xin-Yi,et al."A review on chiral separation by counter-current chromatography: Development, applications and future outlook".JOURNAL OF CHROMATOGRAPHY A 1531(2018):1-12.