QIBEBT-IR
Zinc Oxide Nanoparticle Caused Plasma Metabolomic Perturbations Correlate with Hepatic Steatosis
Zhang, Weidong1; Zhao, Yong1,2; Li, Fuli3; Li, Lan1; Feng, Yanni1; Min, Lingjiang1; Ma, Dongxue1; Yu, Shuai1; Liu, Jing4; Zhang, Hongfu2; Shi, Tianhong5; Li, Fuwei5; Shen, Wei1
2018-01-30
Source PublicationFRONTIERS IN PHARMACOLOGY
ISSN1663-9812
Volume9
AbstractZinc oxide nanoparticles (ZnO NPs), known for their chemical stability and strong adsorption, are used in everyday items such as cosmetics, sunscreens, and prophylactic drugs. However, they have also been found to adversely affect organisms; previously we found that ZnO NPs disrupt pubertal ovarian development, inhibit embryonic development by upsetting gamma-H2AX and NF-kappa B pathways, and even disturb skin stem cells. Non-targeted metabolomic analysis of biological organisms has been suggested as an unbiased tool for the investigation of perturbations in response to NPs and their underlying mechanisms. Although metabolomics has been used in nanotoxicological studies, very few reports have used it to investigate the effects of ZnO NPs exposure. In the current investigation, through a metabolomics-based approach, we discovered that ZnO NPs caused changes in plasma metabolites involved in anti-oxidative mechanisms, energy metabolism, and lipid metabolism in hen livers. These results are in line with earlier findings that ZnO NPs perturb the tricarboxylic acid cycle and in turn result in the use of alternative energy sources. We also found that ZnO NPs disturbed lipid metabolism in the liver and consequently impacted blood lipid balance. Changes in plasma metabolomes were correlated with hepatic steatosis.
SubtypeArticle
KeywordZinc Oxide Nanoparticles Plasma Metabolomics Perturbation Hepatic Steatosis
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.3389/fphar.2018.00057
WOS KeywordOXIDATIVE STRESS ; INDUCED HEPATOTOXICITY ; TOXICITY ; RATS ; TAURINE ; CELLS ; EXPOSURE ; LUNG ; NEPHROTOXICITY ; CYTOTOXICITY
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
Funding OrganizationAgricultural Innovative Project of Shandong Academy of Agricultural Sciences(CXGC2017B02) ; Program for Natural Science Foundation of Shandong Province in China(ZR2015CL045) ; National Natural Science Foundation of China(31302166) ; Qingdao Agricultural University Outstanding Research Foundation
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000423546900001
PublisherFRONTIERS MEDIA SA
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qibebt.ac.cn/handle/337004/10586
Collection中国科学院青岛生物能源与过程研究所
Corresponding AuthorZhao, Yong; Shen, Wei
Affiliation1.Qingdao Agr Univ, Coll Life Sci, Qingdao, Peoples R China
2.Chinese Acad Agr Sci, Inst Anim Sci, State Key Lab Anim Nutr, Beijing, Peoples R China
3.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao, Peoples R China
4.Qingdao Agr Univ, Core Labs, Qingdao, Peoples R China
5.Shandong Acad Agr Sci, Inst Poultry Sci, Jinan, Shandong, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Weidong,Zhao, Yong,Li, Fuli,et al. Zinc Oxide Nanoparticle Caused Plasma Metabolomic Perturbations Correlate with Hepatic Steatosis[J]. FRONTIERS IN PHARMACOLOGY,2018,9.
APA Zhang, Weidong.,Zhao, Yong.,Li, Fuli.,Li, Lan.,Feng, Yanni.,...&Shen, Wei.(2018).Zinc Oxide Nanoparticle Caused Plasma Metabolomic Perturbations Correlate with Hepatic Steatosis.FRONTIERS IN PHARMACOLOGY,9.
MLA Zhang, Weidong,et al."Zinc Oxide Nanoparticle Caused Plasma Metabolomic Perturbations Correlate with Hepatic Steatosis".FRONTIERS IN PHARMACOLOGY 9(2018).
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