Biosynthesis and production of sabinene: current state and perspectives

doi:10.1007/s00253-017-8695-5

QIBEBT-IR > 生物基材料组群

	Biosynthesis and production of sabinene: current state and perspectives
	Cao, Yujin; Zhang, Haibo; Liu, Hui; Liu, Wei; Zhang, Rubing; Xian, Mo; Liu, Huizhou
	2018-02-01
发表期刊	APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
ISSN	0175-7598
卷号	102 期号:4 页码:1535-1544
摘要	Sabinene is an important naturally occurring bicyclic monoterpene which can be used as flavorings, perfume additives, fine chemicals, and advanced biofuels. Up to now, this valuable terpene is commercially unavailable since there is no applicable manufacturing process. Microbial synthesis can be a promising route for sabinene production. In this review, we summarize knowledge about the metabolic pathway and key enzymes for sabinene biosynthesis. Recent advances that have been made in production of sabinene by microbial fermentation are highlighted. In these studies, researchers have identified the general synthetic pathway of sabinene from simple intermediate metabolites. Sabinene synthases of different origins were also cloned and characterized. Additionally, heterologous systems of the model microbes Escherichia coli and Saccharomyces cerevisiae were constructed to produce sabinene. This review also suggests new directions and attempts to gain some insights for achieving an industrial level production of sabinene. The combination of traditional molecular biology with new genome and proteome analysis tools will provide a better view of sabinene biosynthesis and a greater potential of microbial production.
文章类型	Review
关键词	Sabinene Terpene Biosynthetic Pathway Sabinene Synthase Microbial Production
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
DOI	10.1007/s00253-017-8695-5
关键词[WOS]	CELL-FREE SYSTEMS ; ISOPENTENYL DIPHOSPHATE ; ISOPRENOID BIOSYNTHESIS ; ESCHERICHIA-COLI ; BIOTECHNOLOGICAL PRODUCTION ; SACCHAROMYCES-CEREVISIAE ; MONOTERPENE SYNTHASES ; BORNYL DIPHOSPHATE ; ESSENTIAL OILS ; PATHWAY
收录类别	SCI
语种	英语
WOS研究方向	Biotechnology & Applied Microbiology
项目资助者	National Natural Science Foundation of China(31200030) ; Taishan Scholars Climbing Program of Shandong(tspd20150210)
WOS类目	Biotechnology & Applied Microbiology
WOS记录号	WOS:000424053700001
出版者	SPRINGER
引用统计
文献类型	期刊论文
条目标识符	http://ir.qibebt.ac.cn/handle/337004/10582
专题	生物基材料组群
通讯作者	Xian, Mo; Liu, Huizhou
作者单位	Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, CAS Key Lab Biobased Mat, Qingdao 266101, Peoples R China
推荐引用方式 GB/T 7714	Cao, Yujin,Zhang, Haibo,Liu, Hui,et al. Biosynthesis and production of sabinene: current state and perspectives[J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2018,102(4):1535-1544.
APA	Cao, Yujin.,Zhang, Haibo.,Liu, Hui.,Liu, Wei.,Zhang, Rubing.,...&Liu, Huizhou.(2018).Biosynthesis and production of sabinene: current state and perspectives.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,102(4),1535-1544.
MLA	Cao, Yujin,et al."Biosynthesis and production of sabinene: current state and perspectives".APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 102.4(2018):1535-1544.