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Improving phloroglucinol tolerance and production in Escherichia coli by GroESL overexpression
Zhang, Rubing1,2; Cao, Yujin1; Liu, Wei1; Xian, Mo1; Liu, Huizhou1
2017-12-19
发表期刊MICROBIAL CELL FACTORIES
ISSN1475-2859
卷号16
摘要Background: Phloroglucinol is an important chemical which has been successfully produced by engineered Escherichia coli. However, the toxicity of phloroglucinol can enormously inhibit E. coli cell growth and viability, and the productivity is still too low and not economically feasible for industrial applications. Therefore, strain tolerance to toxic metabolites remains a key issue during the production of chemicals using biological processes.
文章类型Article
关键词Groesl Expression Level Tolerance Escherichia Coli Phloroglucinol
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1186/s12934-017-0839-x
关键词[WOS]CLOSTRIDIUM-ACETOBUTYLICUM ; TRANSCRIPTIONAL ANALYSIS ; DIRECTED EVOLUTION ; SOLVENT TOLERANCE ; ACID TOLERANCE ; CHEMICALS ; BUTANOL ; STRESS ; MECHANISMS ; CHAPERONES
收录类别SCI
语种英语
WOS研究方向Biotechnology & Applied Microbiology
项目资助者National Natural Science Foundation of China(21572242) ; Taishan Scholars Climbing Program of Shandong(tspd20150210)
WOS类目Biotechnology & Applied Microbiology
WOS记录号WOS:000418667400001
出版者BIOMED CENTRAL LTD
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文献类型期刊论文
条目标识符http://ir.qibebt.ac.cn/handle/337004/10494
专题中国科学院青岛生物能源与过程研究所
通讯作者Xian, Mo; Liu, Huizhou
作者单位1.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, CAS Key Lab Biobased Mat, Qingdao 266101, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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GB/T 7714
Zhang, Rubing,Cao, Yujin,Liu, Wei,et al. Improving phloroglucinol tolerance and production in Escherichia coli by GroESL overexpression[J]. MICROBIAL CELL FACTORIES,2017,16.
APA Zhang, Rubing,Cao, Yujin,Liu, Wei,Xian, Mo,&Liu, Huizhou.(2017).Improving phloroglucinol tolerance and production in Escherichia coli by GroESL overexpression.MICROBIAL CELL FACTORIES,16.
MLA Zhang, Rubing,et al."Improving phloroglucinol tolerance and production in Escherichia coli by GroESL overexpression".MICROBIAL CELL FACTORIES 16(2017).
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