QIBEBT-IR研究单元&专题: 人事教育处http://ir.qibebt.ac.cn:80/handle/0/1572024-03-28T21:00:12Z2024-03-28T21:00:12ZHighly brominated metabolites from marine red alga Laurencia similis inhibit protein tyrosine phosphatase 1BQin, JianchunSu, HuaZhang, YameiGao, JinmingZhu, LinWu, XianPan, HongyuLi, Xianghttp://ir.qibebt.ac.cn:80/handle/337004/65332019-12-31T08:28:49Z2015-11-02T11:27:34Z题名: Highly brominated metabolites from marine red alga Laurencia similis inhibit protein tyrosine phosphatase 1B
作者: Qin, Jianchun; Su, Hua; Zhang, Yamei; Gao, Jinming; Zhu, Lin; Wu, Xian; Pan, Hongyu; Li, Xiang
摘要: Five new highly brominated metabolites, 3',5',6',6-tetrabromo-2,4-dimethyldiphenyl ether (1), 1,2,5-tribromo-3-bromoamino-7-bromomethylnaphthalene (2), 2,5,8-tribromo-3-bromoamino-7-bromomethylnaphthalene (3), 2,5,6-tribromo-3-bromoamino-7-bromomethylnaphthalene (4) and 2',5',6',5, 6-pentabromo-3',4',3,4-tetramethoxybenzo-phenone (5) were isolated from the red alga Laurencia similis. Their structures were elucidated by spectroscopic methods including one-and two-dimensional NMR as well as HREIMS analysis. Compounds 1 and 5 showed strong inhibitory activities against protein tyrosine phosphatase 1B (PTP1B) with IC(50) of 2.97 and 2.66 mu M, respectively. (C) 2010 Elsevier Ltd. All rights reserved.2015-11-02T11:27:34ZA New Furanone Isolated from a Marine-Derived Actinomycete M159Guo, ShujuSu, HuaLi, XiancuiShi, DayongZhu, Xiaobinhttp://ir.qibebt.ac.cn:80/handle/337004/64802018-08-24T01:42:56Z2015-11-02T11:08:44Z题名: A New Furanone Isolated from a Marine-Derived Actinomycete M159
作者: Guo, Shuju; Su, Hua; Li, Xiancui; Shi, Dayong; Zhu, Xiaobin
摘要: A new furanone, 5-(4',6'-dihydroxy-6'-methyloctyl)furan-2(5H)-one (1), and a known furanone, 5-(6',7'-dihydroxy-6'-methyloctyl)furan-2(5H)-one (2), were isolated from a marine-derived actinomycete (strain No. M159). The structures of these two compounds were determined on the basis of spectroscopic and chemical data.2015-11-02T11:08:44Z